製品の概要

  • 製品名
    Anti-CD8 beta antibody [2ST8.5H7]
    CD8 beta 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2ST8.5H7] to CD8 beta
  • アプリケーション
    適用あり: WB, Flow Cyt, IPmore details
  • 種交差性
    交差種: Human, Cynomolgus monkey
  • 免疫原

    Tissue, cells or virus corresponding to Human CD8 beta. Normal human T lymphocytes.

  • エピトープ
    ab23616 binds to the CD8 beta chain, recognising an epitope that is dependent upon expression of both CD8 alpha and CD8 beta.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: 0.5% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein A purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    2ST8.5H7
  • ミエローマ
    NS1
  • アイソタイプ
    IgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab23616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration.
Flow Cyt 1/1 - 1/10.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
  • 組織特異性
    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
  • 配列類似性
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻訳後修飾
    Phosphorylated as a consequence of T-cell activation.
  • 細胞内局在
    Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD8b antigen antibody
    • CD8 antigen beta polypeptide 1 (p37) antibody
    • CD8 antigen beta polypeptide 1 antibody
    • CD8 beta antibody
    • CD8b antibody
    • CD8b molecule antibody
    • CD8B_HUMAN antibody
    • CD8B1 antibody
    • Leu2 antibody
    • Ly3 antibody
    • LYT3 antibody
    • MGC119115 antibody
    • P37 antibody
    • T cell surface glycoprotein CD8 beta chain antibody
    • T lymphocyte surface glycoprotein beta chain antibody
    • T-cell surface glycoprotein CD8 beta chain antibody
    see all

参考文献

This product has been referenced in:
  • Clement M  et al. Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. J Immunol 187:654-63 (2011). Functional Studies . Read more (PubMed: 21677135) »
  • Yoshino N  et al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000). Read more (PubMed: 10889948) »

See all 2 Publications for this product

レビューと Q&A

Thank you for contacting us. As discussed on the phone, this antibody is not conjugated and in order to detect it you would therefore either need a secondary antibody or to conjugate the antibody itself. We have several secondary antibodies to choose f...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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