製品の概要
- 製品名Anti-CD8 beta antibody [2ST8.5H7]
CD8 beta 一次抗体 製品一覧 - 製品の詳細Mouse monoclonal [2ST8.5H7] to CD8 beta
- アプリケーション適用あり: WB, Flow Cyt, IPmore details
- 種交差性交差種: Human, Cynomolgus monkey
- 免疫原
Tissue, cells or virus corresponding to Human CD8 beta. Normal human T lymphocytes.
- エピトープab23616 binds to the CD8 beta chain, recognising an epitope that is dependent upon expression of both CD8 alpha and CD8 beta.
製品の特性
- 製品の状態Liquid
- 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
- バッファーPreservative: 0.09% Sodium Azide
Constituents: 0.5% BSA, PBS, pH 7.4 -
Concentration information loading... - 精製度Protein A purified
- ポリ/モノモノクローナル
- クローン名2ST8.5H7
- ミエローマNS1
- アイソタイプIgG2a
- 研究分野
関連製品
- Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab23616 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use at an assay dependent concentration. | |
| Flow Cyt | 1/1 - 1/10. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
|
| IP | Use at an assay dependent concentration. |
ターゲット情報
- 機能Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
- 組織特異性Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
- 配列類似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
- 翻訳後修飾Phosphorylated as a consequence of T-cell activation.
- 細胞内局在Secreted and Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 926 Human
- Omim: 186730 Human
- SwissProt: P10966 Human
- Unigene: 405667 Human
-
別名
- CD8b antigen antibody
- CD8 antigen beta polypeptide 1 (p37) antibody
- CD8 antigen beta polypeptide 1 antibody
see all
Anti-CD8 beta antibody [2ST8.5H7] (ab23616) 使用論文
This product has been referenced in:
- Clement M et al. Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. J Immunol 187:654-63 (2011). Functional Studies . Read more (PubMed: 21677135) »
- Yoshino N et al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000). Read more (PubMed: 10889948) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"