製品の概要

  • 製品名
    Anti-CD8 beta antibody [2ST8.5H7]
    CD8 beta 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2ST8.5H7] to CD8 beta
  • 由来種
    Mouse
  • アプリケーション
    適用あり: WB, Flow Cyt, IPmore details
  • 種交差性
    交差種: Human, Cynomolgus monkey
  • 免疫原

    Tissue, cells or virus corresponding to Human CD8 beta. Normal human T lymphocytes.

  • エピトープ
    ab23616 binds to the CD8 beta chain, recognising an epitope that is dependent upon expression of both CD8 alpha and CD8 beta.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: 0.5% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein A purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    2ST8.5H7
  • ミエローマ
    NS1
  • アイソタイプ
    IgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab23616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration.
Flow Cyt 1/1 - 1/10.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
  • 組織特異性
    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
  • 配列類似性
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻訳後修飾
    Phosphorylated as a consequence of T-cell activation.
  • 細胞内局在
    Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
    • 別名
      • CD8b antigen antibody
      • CD8 antigen beta polypeptide 1 (p37) antibody
      • CD8 antigen beta polypeptide 1 antibody
      • CD8 beta antibody
      • CD8b antibody
      • CD8b molecule antibody
      • CD8B_HUMAN antibody
      • CD8B1 antibody
      • Leu2 antibody
      • Ly3 antibody
      • LYT3 antibody
      • MGC119115 antibody
      • P37 antibody
      • T cell surface glycoprotein CD8 beta chain antibody
      • T lymphocyte surface glycoprotein beta chain antibody
      • T-cell surface glycoprotein CD8 beta chain antibody
      see all

    参考文献

    This product has been referenced in:
    • Clement M  et al. Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. J Immunol 187:654-63 (2011). Functional Studies . Read more (PubMed: 21677135) »
    • Yoshino N  et al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000). Read more (PubMed: 10889948) »

    See all 2 Publications for this product

    ab23616 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    レビューと Q&A

    レビューを送る 質問を送る

    1 Review or Q&A

    10
    Votes: Highest First

    Phone enquiry in regards to Anti-CD8 beta antibody [2ST8.5H7] (ab23616) and the nature of the conjugation.

    Thank you for contacting us. As discussed on the phone, this antibody is not conjugated and in order to detect it you would therefore either need a secondary antibody or to conjugate the antibody itself. We have several secondary antibodies to choose f...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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