製品の概要

  • 製品名
    Anti-CD8 antibody [LT8] (FITC)
    CD8 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [LT8] to CD8 (FITC)
  • 標識
    FITC. Ex: 493nm, Em: 528nm
  • 特異性
    ab28010 recognises CD8 antigen.
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human, Rhesus monkey
  • 免疫原

    Tissue/ cell preparation (Human) - normal human blood lymphocytes.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab28010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt 1/1 - 1/5.

10µl of the working dilution for 106 cells or 100µl human whole blood.
ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能
    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
  • 関連疾患
    Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
  • 配列類似性
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻訳後修飾
    All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • 細胞内局在
    Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 製品の状態
    CD8 beta tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. CD8 beta PTM: Phosphorylated as a consequence of T-cell activation.
  • 別名
    • CD8 antibody
    • CD8 antigen, alpha polypeptide (p32) antibody
    • CD8a antibody
    • CD8a antigen antibody
    • CD8a molecule antibody
    • CD8A_HUMAN antibody
    • Leu2 antibody
    • Leu2 T lymphocyte antigen antibody
    • MAL antibody
    • OKT8 T cell antigen antibody
    • p32 antibody
    • T cell antigen Leu2 antibody
    • T cell co receptor antibody
    • T-cell surface glycoprotein CD8 alpha chain antibody
    • T-lymphocyte differentiation antigen T8/Leu-2 antibody
    • T8 T cell antigen antibody
    see all

画像

  • Staining of human peripheral blood lymphocytes with mouse anti-human CD8 - FITC conjugate (ab28010).

プロトコール

参考文献

This product has been referenced in:
  • Bacac M  et al. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. Clin Cancer Res 22:3286-97 (2016). Read more (PubMed: 26861458) »
  • Belharazem D  et al. cFLIP overexpression in T cells in thymoma-associated myasthenia gravis. Ann Clin Transl Neurol 2:894-905 (2015). Flow Cyt ; Human . Read more (PubMed: 26401511) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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