製品の概要

  • 製品名Anti-CD8 antibody [C8/144B], prediluted
    CD8 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [C8/144B] to CD8, prediluted
  • 特異性We have data to indicate that this antibody may not cross react with Rat. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • アプリケーション適用あり: IHC-Fr, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A 13 amino acid synthetic peptide from the C terminal cytoplasmic domain of alpha chain of human CD8 molecule

  • エピトープC terminal
  • ポジティブ・コントロール
    • Human tonsil and lymph node tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab75129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration. PubMed: 20596022
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
  • 関連疾患Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
  • 配列類似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻訳後修飾All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 製品の状態CD8 beta tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. CD8 beta PTM: Phosphorylated as a consequence of T-cell activation.
  • 別名
    • CD8 antibody
    • CD8 antigen, alpha polypeptide (p32) antibody
    • CD8a antibody
    • CD8a antigen antibody
    • CD8a molecule antibody
    • CD8A_HUMAN antibody
    • Leu2 antibody
    • Leu2 T lymphocyte antigen antibody
    • MAL antibody
    • OKT8 T cell antigen antibody
    • p32 antibody
    • T cell antigen Leu2 antibody
    • T cell co receptor antibody
    • T-cell surface glycoprotein CD8 alpha chain antibody
    • T-lymphocyte differentiation antigen T8/Leu-2 antibody
    • T8 T cell antigen antibody
    see all

Anti-CD8 antibody [C8/144B], prediluted 画像

  • ab75129, at a 1/25 dilution, staining CD8 in formalin fixed, paraffin embedded human tonsil tissue by Immunohistochemistry, using peroxidase conjugate and DAB chromogen. Note membrane staining of T cells.

Anti-CD8 antibody [C8/144B], prediluted (ab75129) 使用論文

This product has been referenced in:
  • Petukhova L  et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 466:113-7 (2010). IHC-Fr ; Human . Read more (PubMed: 20596022) »
  • Ratajczak P  et al. Th17/Treg ratio in human graft-versus-host disease. Blood 116:1165-71 (2010). IHC-P ; Human . Read more (PubMed: 20484086) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"