FITC Anti-CD8 alpha 抗体 [3-298] (ab24910)
Key features and details
- FITC Mouse monoclonal [3-298] to CD8 alpha
- Suitable for: Flow Cyt
- Reacts with: Chicken
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
製品の概要
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製品名
FITC Anti-CD8 alpha antibody [3-298]
CD8 alpha 一次抗体 製品一覧 -
製品の詳細
FITC Mouse monoclonal [3-298] to CD8 alpha -
由来種
Mouse -
標識
FITC. Ex: 493nm, Em: 528nm -
特異性
This antibody recognises CD8a. -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Chicken
交差が予測される動物種: Turkey -
免疫原
Tissue, cells or virus corresponding to CD8 alpha. Chicken thymocytes
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ポジティブ・コントロール
- Flow Cyt: Chicken peripheral blood lymphocytes.
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特記事項
In chicken, the CD8 molecule is present in two forms: (i) a homodimer of two alpha chains, and (ii) a heterodimer of an alpha chain and a beta chain. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells and 50% of spleen cells, but <1% of cells in the bursa and bone marrow. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha and CD8 beta chains, a relatively large proportion of the CD8+ TCR gamma delta cells in the spleens of embryos and young chicks express only the alpha chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved, but there is a population of TCR gamma delta CD8 alpha beta cells in the chicken that is not found in rodents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Affinity purified -
一次抗体 備考
In chicken, the CD8 molecule is present in two forms: (i) a homodimer of two alpha chains, and (ii) a heterodimer of an alpha chain and a beta chain. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells and 50% of spleen cells, but <1% of cells in the bursa and bone marrow. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha and CD8 beta chains, a relatively large proportion of the CD8+ TCR gamma delta cells in the spleens of embryos and young chicks express only the alpha chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved, but there is a population of TCR gamma delta CD8 alpha beta cells in the chicken that is not found in rodents. -
ポリ/モノ
モノクローナル -
クローン名
3-298 -
アイソタイプ
IgG2b -
軽鎖の種類
kappa -
研究分野
関連製品
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab24910の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
Use at an assay dependent concentration.
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特記事項 |
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Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
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機能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
関連疾患
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
配列類似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻訳後修飾
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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別名
- alpha polypeptide (p32) antibody
- CD_antigen=CD8a antibody
- CD8 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab24910 は論文での使用が確認できていません。