製品の概要

  • 製品名Anti-CD79b antibody [AT107-2] (FITC)
    CD79b 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [AT107-2] to CD79b (FITC)
  • 標識FITC. Ex: 493nm, Em: 528nm
  • 特異性Recognises an intracellular region of human CD79b We have data to indicate that this antibody may not cross react with Chicken. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Mouse, Rat, Dog, Human, Pig
  • 免疫原

    Synthetic peptide corresponding to an intracellular region of human CD79b.

  • ポジティブ・コントロール
    • Rat peripheral blood lymphocytes.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名AT107-2
  • ミエローマNS1
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab33296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報Flow Cyt: Use 10µl for 106 cells in 100µl.
    Note: Membrane permeabilisation is required for this application.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
    • 組織特異性B-cells.
    • 関連疾患Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
    • 配列類似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Contains 1 ITAM domain.
    • 翻訳後修飾Phosphorylated on tyrosine upon B-cell activation.
    • 細胞内局在Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AGM6 antibody
      • B cell antigen receptor complex associated protein beta chain antibody
      • B cell specific glycoprotein B29 antibody
      • B-cell antigen receptor complex-associated protein beta chain antibody
      • B-cell-specific glycoprotein B29 antibody
      • B29 antibody
      • B29/Ig-beta/CD79b antibody
      • CD 79b antibody
      • CD79b antibody
      • CD79b antigen (immunoglobulin associated beta) antibody
      • CD79b antigen antibody
      • CD79b molecule antibody
      • CD79b molecule immunoglobulin associated beta antibody
      • CD79b protein antibody
      • CD79B_HUMAN antibody
      • Ig beta antibody
      • Ig-beta antibody
      • IGB antibody
      • Igbeta antibody
      • Immunoglobulin associated B29 antibody
      • Immunoglobulin associated B29 protein antibody
      • Immunoglobulin associated beta antibody
      • Immunoglobulin associated protein antibody
      • Immunoglobulin-associated B29 protein antibody
      • MGC108607 antibody
      see all

    Anti-CD79b antibody [AT107-2] (FITC) 画像

    • Staining of rat peripheral blood lymphocytes with ab33296 after permeabilisation.

    Anti-CD79b antibody [AT107-2] (FITC) (ab33296) 使用論文

    This product has been referenced in:
    • Sun Z  et al. Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. Int J Mol Med 33:1097-109 (2014). Flow Cyt ; Rat . Read more (PubMed: 24573542) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab33296.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"