製品の概要

  • 製品名Anti-CD79a antibody [SP18]
    CD79a 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [SP18] to CD79a
  • 特異性ab16698 recognises CD79a. We have data to indicate that this antibody may not cross react with Opossum. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • アプリケーション適用あり: Flow Cyt, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Pig, Monkey
  • 免疫原

    Synthetic peptide derived from N terminal region of human CD79a protein.

  • エピトープab16698 reacts with an epitope located in the N terminal region of CD79a.
  • ポジティブ・コントロール
    • Human tonsil and B cell lymphoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab16698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.
  • 組織特異性B-cells.
  • 関連疾患Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3) [MIM:613501]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
  • 配列類似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻訳後修飾Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
  • 細胞内局在Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B lymphocyte-specific MB1 protein antibody
    • B-cell antigen receptor complex-associated protein alpha chain antibody
    • CD 79a antibody
    • CD79a antibody
    • CD79a antigen (immunoglobulin-associated alpha) antibody
    • CD79A antigen antibody
    • CD79a molecule, immunoglobulin-associated alpha antibody
    • CD79A_HUMAN antibody
    • Ig alpha antibody
    • Ig-alpha antibody
    • IGA antibody
    • IgM-alpha antibody
    • Immunoglobulin-associated alpha antibody
    • Ly54 antibody
    • MB-1 membrane glycoprotein antibody
    • MB1 antibody
    • Membrane-bound immunoglobulin-associated protein antibody
    • Surface IgM-associated protein antibody
    see all

Anti-CD79a antibody [SP18] 画像

  • Flow cytometric analysis of rabbit anti-CD79a (SP18) antibody ab16698 (1/100) in Jurkat cells (green) compared to negative control of rabbit IgG (blue).

  • Ab16698, at a dilution of 1/100, staining formalin fixed paraffin embedded human tonsil tissue sections by Immunohistochemistry.

Anti-CD79a antibody [SP18] (ab16698) 使用論文

ab16698 has not yet been referenced specifically in any publications.

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