製品の概要

  • 製品名
    Anti-CD72.1 antibody [10-1.D.2]
  • 製品の詳細
    Mouse monoclonal [10-1.D.2] to CD72.1
  • アプリケーション
    適用あり: Flow Cyt, Blockingmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Tissue/ cell preparation (Mouse) - DBA/2 mouse spleen cells.

  • 特記事項


    The 10-1.D.2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing.1 However, 10-1.D.2 can itself trigger a positive signal by binding CD72. This antibody has been shown to be useful in In vitro blocking and proliferation studies.

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    pH: 8.20
    Constituent: 100% Borate buffered saline
  • Concentration information loading...
  • 精製度
    IgG fraction
  • 一次抗体 備考
    The 10-1.D.2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing.1 However, 10-1.D.2 can itself trigger a positive signal by binding CD72. This antibody has been shown to be useful in In vitro blocking and proliferation studies.
  • ポリ/モノ
    モノクローナル
  • クローン名
    10-1.D.2
  • アイソタイプ
    IgG2b
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab25320 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
Blocking Use at an assay dependent concentration.

ターゲット情報

  • 関連性
    Murine CD72.1/Lyb2.1, a type II integral membrane glycoprotein and a member of the C lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb2.1 allotype. CD72.1 is the ligand of CD5 (Ly1) which is distributed on all T cells and a small number of B cells.
  • 細胞内局在
    Type II membrane protein.
  • 参照データベース
  • 別名
    • CD72 antigen antibody
    • Ly19 antibody
    • Ly32 antibody
    • LYB2 antibody
    • Lym19 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Xing C  et al. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. J Leukoc Biol 97:547-56 (2015). Read more (PubMed: 25516754) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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