製品の概要

  • 製品名
    Anti-CD59 antibody [MEM-43] (Allophycocyanin)
    CD59 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MEM-43] to CD59 (Allophycocyanin)
  • 標識
    Allophycocyanin. Ex: 645nm, Em: 660nm
  • 特異性
    ab36467 recognises CD59 antigen.
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human thymocytes and T lymphocytes

  • エピトープ
    Reacts with the well defined epitope (W40, R-53) on CD59 molecule
  • ポジティブ・コントロール
    • Human whole blood

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab36467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報
    Flow Cyt: use 20µl reagent/100µl whole blood or 106 cells in a suspension.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
      The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
    • 関連疾患
      Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:612300].
    • 配列類似性
      Contains 1 UPAR/Ly6 domain.
    • 翻訳後修飾
      N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
      Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.
    • 細胞内局在
      Cell membrane. Secreted. Soluble form found in a number of tissues.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 16.3A5 antibody
      • 1F5 antibody
      • 1F5 antigen antibody
      • 20 kDa homologous restriction factor antibody
      • CD 59 antibody
      • CD_antigen=CD59 antibody
      • CD59 antibody
      • CD59 antigen antibody
      • CD59 antigen complement regulatory protein antibody
      • CD59 antigen p18 20 antibody
      • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody
      • CD59 glycoprotein antibody
      • CD59 molecule antibody
      • CD59 molecule complement regulatory protein antibody
      • CD59_HUMAN antibody
      • Cd59a antibody
      • Complement regulatory protein antibody
      • EJ16 antibody
      • EJ30 antibody
      • EL32 antibody
      • FLJ38134 antibody
      • FLJ92039 antibody
      • G344 antibody
      • HRF 20 antibody
      • HRF-20 antibody
      • HRF20 antibody
      • Human leukocyte antigen MIC11 antibody
      • Ly 6 like protein antibody
      • Lymphocytic antigen CD59/MEM43 antibody
      • MAC inhibitory protein antibody
      • MAC IP antibody
      • MAC-inhibitory protein antibody
      • MAC-IP antibody
      • MACIF antibody
      • MACIP antibody
      • MEM43 antibody
      • MEM43 antigen antibody
      • Membrane attack complex (MAC) inhibition factor antibody
      • Membrane attack complex inhibition factor antibody
      • Membrane inhibitor of reactive lysis antibody
      • MGC2354 antibody
      • MIC11 antibody
      • MIN1 antibody
      • MIN2 antibody
      • MIN3 antibody
      • MIRL antibody
      • MSK21 antibody
      • p18 20 antibody
      • Protectin antibody
      • Surface antigen recognized by monoclonal antibody 16.3A5 antibody
      • T cell activating protein antibody
      see all

    画像

    • Flow Cytometry analysis of HL-60 (positive) and SP2 (negative) cells labeling CD59 with Anti-CD59 antibody [MEM-43] (Allophycocyanin) (ab36467).

    プロトコール

    参考文献

    This product has been referenced in:

    See 1 Publication for this product

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