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Tissue/ cell preparation (Human). (Leucocytes from a patient suffering from a LGL-type leukaemia).
The antibody reacts with CD53 antigen, a glycoprotein of 32-40 kDa belonging to the tetraspans family (TM4SF). CD53 antigen is exclusivelly expressed on leucocytes (not present on platelets, red blood cells and non-hematopoietic cells). CD53 is important for signal transduction. CD53 cross-linking promotes activation of human B cells and rat macrophages.
Our Abpromise guarantee covers the use of ab667 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use a concentration of 4 µg/ml.|
|IHC-Fr||Use at an assay dependent concentration. Can be used to discriminate lymphomas from other tumors.|
|IP||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration.|
|ICC/IF||Use at an assay dependent concentration. PubMed: 17438075|
|Functional Studies||Use at an assay dependent concentration. Induces activation of monocytes and B lymphocytes.|
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