Anti-CD45RA 抗体 [GRT22] (Allophycocyanin) (ab90972)

製品の概要

  • 製品名
    Anti-CD45RA antibody [GRT22] (Allophycocyanin)
    CD45RA 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [GRT22] to CD45RA (Allophycocyanin)
  • 標識
    Allophycocyanin. Ex: 645nm, Em: 660nm
  • 特異性
    ab90972 recognizes all CD45 molecules containing the A region exon.
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Fresh Human lymph node lymphocytes depleted of surface immunoglobulin positive cells.

  • 特記事項


    ab90972 allows simultaneous detection and enumeration of the helper/inducer T cell subset and CD45RA+ cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 20µl for 106 cells.

ターゲット情報

  • 機能
    Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
  • 関連疾患
    Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive
    Multiple sclerosis
  • 配列類似性
    Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 tyrosine-protein phosphatase domains.
  • ドメイン
    The first PTPase domain interacts with SKAP1.
  • 翻訳後修飾
    Heavily N- and O-glycosylated.
  • 細胞内局在
    Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B220 antibody
    • CD45 antibody
    • CD45 antigen antibody
    • CD45R antibody
    • EC 3.1.3.48 antibody
    • GP180 antibody
    • L-CA antibody
    • LCA antibody
    • Leukocyte common antigen antibody
    • Loc antibody
    • Ly-5 antibody
    • LY5 antibody
    • Ly5, homolog of antibody
    • Lymphocyte antigen 5 antibody
    • Lyt-4 antibody
    • Protein tyrosine phosphatase, receptor type C antibody
    • Protein tyrosine phosphatase, receptor type, C antibody
    • Protein tyrosine phosphatase, receptor type, c polypeptide antibody
    • Ptprc antibody
    • PTPRC_HUMAN antibody
    • Receptor-type tyrosine-protein phosphatase C antibody
    • RT7 antibody
    • T200 antibody
    • T200 glycoprotein antibody
    • T200 leukocyte common antigen antibody
    see all

プロトコール

参考文献

ab90972 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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