Anti-CD41 抗体 [MEM-06] (Allophycocyanin) (ab55866)


  • 製品名Anti-CD41 antibody [MEM-06] (Allophycocyanin)
    CD41 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MEM-06] to CD41 (Allophycocyanin)
  • 標識Allophycocyanin. Ex: 645nm, Em: 660nm
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Tissue, cells or virus corresponding to Human CD41. Leukocytes of patient suffering from LGL-type leukaemia.
    Database link: P08514



Our Abpromise guarantee covers the use of ab55866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報Flow Cyt: Use 10µl for 106 cells in a suspension, or 100ul of whole blood.
    The content of a vial (1 ml) is sufficient for 100 tests.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    • 組織特異性Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
    • 関連疾患Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
    • 配列類似性Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • antigen CD41 antibody
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD41 antibody
      • CD41B antibody
      • form 2 antibody
      • GP2B antibody
      • GPalpha IIb antibody
      • GPIIb antibody
      • GT antibody
      • GTA antibody
      • HPA3 antibody
      • Integrin alpha 2b antibody
      • Integrin alpha IIb antibody
      • Integrin alpha-IIb light chain antibody
      • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
      • ITA2B_HUMAN antibody
      • Itga2b antibody
      • ITGAB antibody
      • platelet fibrinogen receptor, alpha subunit antibody
      • platelet glycoprotein IIb of IIb/IIIa complex antibody
      • Platelet membrane glycoprotein IIb antibody
      • platelet specific antigen BAK antibody
      • PPP1R93 antibody
      see all

    Anti-CD41 antibody [MEM-06] (Allophycocyanin) (ab55866) 使用論文

    ab55866 has not yet been referenced specifically in any publications.

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