Anti-CD40L 抗体 [MR-1] (ab99894)

製品の概要

• 製品名Anti-CD40L antibody [MR-1]
  CD40L 一次抗体 製品一覧
• 製品の詳細
  Armenian Hamster monoclonal [MR-1] to CD40L
• 特異性This antibody detects mouse CD154 / CD40L (CD40 ligand), a 39 kDa cell surface glycoprotein expressed predominantly on activated CD4+ lymphocytes.
• アプリケーション適用あり: IHC-P, IHC-Fr, IP, Functional Studies, ICC, Flow Cytmore details
• 種交差性
  交差種: Mouse
  
• 免疫原

  Tissue/ cell preparation - activated mouse Th1 clone D1.6

• ポジティブ･コントロール
  • 6-8 hour activated mouse splenocytes
• 特記事項

  
  

  Functional Application: Blocking T cell costimulation in vivo.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 15mM Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• 精製度Protein A purified
• 特記事項（精製）Purified from cell culture supernatant (> 95% by SDS-PAGE)
• 一次抗体 備考Functional Application: Blocking T cell costimulation in vivo.
• ポリ/モノモノクローナル
• クローン名MR-1
• アイソタイプIgG1
• 研究分野
  • Immunology
  • Adaptive Immunity
  • T Cells
  • CD

  • Immunology
  • Immunoglobulins
  • Class Switching

  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Cardiovascular
  • Atherosclerosis
  • Thrombosis
  • Platelets

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Innate and adaptive immunity

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

アプリケーション

ターゲット情報

• 機能Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
  Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
• 組織特異性Specifically expressed on activated CD4+ T-lymphocytes.
• 関連疾患Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
• 配列類似性Belongs to the tumor necrosis factor family.
• 翻訳後修飾The soluble form derives from the membrane form by proteolytic processing.
  N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
  Not O-glycosylated.
• 細胞内局在Secreted and Cell membrane.

• Target information above from: UniProt accession P29965 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 21947 Mouse
  • SwissProt: P27548 Mouse
  • Unigene: 4861 Mouse
• 別名
  • CD 40L antibody
  • CD154 antibody
  • CD40 antigen ligand antibody

  • CD40 ligand antibody
  • CD40 ligand, soluble form antibody
  • CD40-L antibody
  • CD40L antibody
  • CD40L_HUMAN antibody
  • CD40LG antibody
  • gp39 antibody
  • hCD40L antibody
  • HIGM1 antibody
  • IGM antibody
  • IMD3 antibody
  • T B cell activating molecule antibody
  • T BAM antibody
  • T-cell antigen Gp39 antibody
  • TNF-related activation protein antibody
  • TNFSF5 antibody
  • TrAP antibody
  • Tumor necrosis factor (ligand) superfamily member 5 antibody
  • Tumor necrosis factor ligand superfamily member 5 antibody

  see all