Anti-CD40L 抗体 [2B10] (ab28084)

製品の概要

  • 製品名Anti-CD40L antibody [2B10]
    CD40L 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2B10] to CD40L
  • 特異性This antibody is specific to soluble CD40L, and can be used for detection of human sCD40L in serum.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant soluble CD40L (Human) conjugated to BSA.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab28084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 29 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
      Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
    • 組織特異性Specifically expressed on activated CD4+ T-lymphocytes.
    • 関連疾患Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
    • 配列類似性Belongs to the tumor necrosis factor family.
    • 翻訳後修飾The soluble form derives from the membrane form by proteolytic processing.
      N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
      Not O-glycosylated.
    • 細胞内局在Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CD 40L antibody
      • CD154 antibody
      • CD40 antigen ligand antibody
      • CD40 ligand antibody
      • CD40 ligand, soluble form antibody
      • CD40-L antibody
      • CD40L antibody
      • CD40L_HUMAN antibody
      • CD40LG antibody
      • gp39 antibody
      • hCD40L antibody
      • HIGM1 antibody
      • IGM antibody
      • IMD3 antibody
      • T B cell activating molecule antibody
      • T BAM antibody
      • T-cell antigen Gp39 antibody
      • TNF-related activation protein antibody
      • TNFSF5 antibody
      • TrAP antibody
      • Tumor necrosis factor (ligand) superfamily member 5 antibody
      • Tumor necrosis factor ligand superfamily member 5 antibody
      see all

    Anti-CD40L antibody [2B10] (ab28084) 使用論文

    ab28084 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your reply.

    First, I apologize but the immunogen I passed along was the sequence of the entire CD40 protein. However the actual immunogen sequence only consists of the soluble form of the protein, amino acids 113 - 261. I have i...

    Read More

    Sorry the sequence was not in the email. I can see it in the email I sent out but something must have changed during transit. Here it is again below and as an attachement.


    >sp|P29965|CD40L_HUMAN CD40 ligand OS=Homo sapiens GN=CD40LG P...

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    Thank you for your enquiry.

    Here is the sequence of the immunogen:


    >sp|P29965|CD40L_HUMAN CD40 ligand OS=Homo sapiens GN=CD40LG PE=1 SV=1
    MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLH
    EDFVFMKTIQRCNTG...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"