Anti-CD40 抗体 [1C10] (Allophycocyanin) (ab25567)
製品の概要
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製品名Anti-CD40 antibody [1C10] (Allophycocyanin)
CD40 一次抗体 製品一覧 -
製品の詳細Rat monoclonal [1C10] to CD40 (Allophycocyanin)
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由来種Rat
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標識Allophycocyanin. Ex: 645nm, Em: 660nm
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アプリケーション適用あり: Flow Cyt, IPmore details
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種交差性交差種: Mouse
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免疫原
The details of the immunogen for this antibody are not available.
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特記事項
This agonistic antibody closely resembles the gp39/CD40 ligand in it's ability to stimulate the proliferation of small, resting B lymphocytes in the absence of other cofactors. This antibody has been shown to be useful in studies of the 'in vitro' induction of proliferation of mature B lymphocytes.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, PBS and stabilizing agent. -
Concentration information loading... -
精製度Affinity purified
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一次抗体 備考This agonistic antibody closely resembles the gp39/CD40 ligand in it's ability to stimulate the proliferation of small, resting B lymphocytes in the absence of other cofactors. This antibody has been shown to be useful in studies of the 'in vitro' induction of proliferation of mature B lymphocytes.
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ポリ/モノモノクローナル
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クローン名1C10
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アイソタイプIgG2a
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軽鎖の種類kappa
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研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab25567 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | Use 0.5µg for 106 cells. | |
| IP | Use at an assay dependent dilution. |
ターゲット情報
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機能Receptor for TNFSF5/CD40LG.
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組織特異性B-cells and in primary carcinomas.
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関連疾患Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
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配列類似性Contains 4 TNFR-Cys repeats.
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細胞内局在Secreted and Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 21939 Mouse
- SwissProt: P27512 Mouse
- Unigene: 271833 Mouse
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別名
- AI326936 antibody
- B cell associated molecule CD40 antibody
- B cell surface antigen CD40 antibody
see all
参考文献
This product has been referenced in:
- Mao XJ et al. TNF-alpha receptor 1 deficiency reduces antigen-presenting capacity of Schwann cells and ameliorates experimental autoimmune neuritis in mice. Neurosci Lett 470:19-23 (2010). Flow Cyt ; Mouse . Read more (PubMed: 20035831) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"