Tissue/ cell preparation (Mouse) - cloned mouse CTL line V4.
特記事項This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.
This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
保存方法Shipped at 4°C. Store at +4°C.
バッファーPreservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, 0.2% Gelatin, PBS and a stabilizing agent.
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一次抗体 備考This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
翻訳後修飾Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
細胞内局在Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.