製品の概要

  • 製品名Anti-CD4 antibody [74-12-4] (PE/Cy5®)
    CD4 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [74-12-4] to CD4 (PE/Cy5®)
  • 標識PE/Cy5®. Ex: 496nm, Em: 670nm
  • 特異性ab25408 recognises CD4.
  • アプリケーション適用あり: Flow Cyt, IP, Functional Studiesmore details
  • 種交差性
    交差種: Pig
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 特記事項This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab25408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
IP
Functional Studies
  • 追加情報Flow Cyt: Use 0.2µg for 106 cells.
    FuncS (Cytotoxicity assays): Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
    • 配列類似性Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻訳後修飾Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
    • 細胞内局在Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
    • Information by UniProt
    • 別名
      • CD 4 antibody
      • CD4 (L3T4) antibody
      • CD4 antibody
      • CD4 antigen (p55) antibody
      • CD4 antigen antibody
      • CD4 molecule antibody
      • CD4 receptor antibody
      • CD4+ Lymphocyte deficiency, included antibody
      • CD4_HUMAN antibody
      • CD4mut antibody
      • L3T4 antibody
      • Leu3 antibody
      • Ly-4 antibody
      • Lymphocyte antigen CD4 antibody
      • MGC165891 antibody
      • OTTHUMP00000238897 antibody
      • p55 antibody
      • T cell antigen T4 antibody
      • T cell antigen T4/LEU3 antibody
      • T cell differentiation antigen L3T4 antibody
      • T cell OKT4 deficiency, included antibody
      • T cell surface antigen T4/Leu 3 antibody
      • T cell surface antigen T4/Leu3 antibody
      • T cell surface glycoprotein CD4 antibody
      • T-cell surface antigen T4/Leu-3 antibody
      • T-cell surface glycoprotein CD4 antibody
      • W3/25 antibody
      • W3/25 antigen antibody
      see all

    Anti-CD4 antibody [74-12-4] (PE/Cy5®) (ab25408) 使用論文

    This product has been referenced in:
    • Smith CV  et al. In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine. J Immunother Emphasis Tumor Immunol 16:105-14 (1994). Read more (PubMed: 7804525) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab25408.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"