The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 10µl of neat antibody to label 106 cells or 100µl of whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only.
Belongs to the GDA1/CD39 NTPase family.
The N-terminus is blocked. Palmitoylated in the N-terminal part.
Clark RA et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med205:2221-34 (2008).
Read more (PubMed: 18794336) »
Aversa GG et al. Detection of a late lymphocyte activation marker by A1, a new monoclonal antibody. Transplant Proc20:49-52 (1988).
Read more (PubMed: 2830689) »