Anti-CD33 抗体 [WM53] (PerCP) (ab124531)
製品の概要
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製品名Anti-CD33 antibody [WM53] (PerCP)
CD33 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [WM53] to CD33 (PerCP)
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由来種Mouse
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標識PerCP. Ex: 482nm, Em: 675nm
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アプリケーション適用あり: Flow Cytmore details
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種交差性交差種: Human, Non human primates
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免疫原
Human AML cells.
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ポジティブ･コントロール
- Human blood cells
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C.
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バッファーPreservative: 0.1% Sodium azide
Constituents: 99% PBS, 0.2% BSA -
Concentration information loading... -
精製度Size exclusion
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ポリ/モノモノクローナル
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クローン名WM53
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アイソタイプIgG1
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研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab124531 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | Use 10µl for 106 cells. ab118658 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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ターゲット情報
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機能Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
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組織特異性Monocytic/myeloid lineage cells.
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配列類似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
ドメインContains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
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翻訳後修飾Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
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細胞内局在Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 945 Human
- Omim: 159590 Human
- SwissProt: P20138 Human
- Unigene: 83731 Human
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別名
- CD 33 antibody
- CD33 antibody
- CD33 antigen (gp67) antibody
see all
プロトコール
参考文献
This product has been referenced in:
- Hernández-Caselles T et al. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol 79:46-58 (2006). Read more (PubMed: 16380601) »
- Garnache-Ottou F et al. Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. Blood 105:1256-64 (2005). Read more (PubMed: 15388576) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"