Anti-CD33 抗体 [WM53] (ab30371)

製品の概要

• 製品名
  Anti-CD33 antibody [WM53]
  CD33 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [WM53] to CD33
• アプリケーション
  適用あり: ICC, Flow Cyt, IP, WB, IHC-Frmore details
  適用なし: IHC-P
• 種交差性
  交差種: Human
  
• 免疫原

  Human AML cells.

• ポジティブ･コントロール
  • Lymphatic tissue

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• バッファー
  Preservative: .09% Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• 精製度
  Protein G purified
• 特記事項（精製）
  Purified from tissue culture supernatant.
• ポリ/モノ
  モノクローナル
• クローン名
  WM53
• ミエローマ
  NS1
• アイソタイプ
  IgG1
• 研究分野
  • Immunology
  • Cell Type Markers
  • CD
  • Myeloid Cells

  • Stem Cells
  • Hematopoietic Progenitors
  • Hematopoietic Stem Cells
  • Human Lineage Negative

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
• Conjugation kits
  • PE / R-Phycoerythrin Conjugation Kit (ab102918)
  • APC Conjugation Kit (ab201807)

アプリケーション

ターゲット情報

• 機能
  Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
• 組織特異性
  Monocytic/myeloid lineage cells.
• 配列類似性
  Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• ドメイン
  Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
• 翻訳後修飾
  Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
• 細胞内局在
  Cell membrane.

• Target information above from: UniProt accession P20138 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 945 Human
  • Omim: 159590 Human
  • SwissProt: P20138 Human
  • Unigene: 83731 Human
• 別名
  • CD 33 antibody
  • CD33 antibody
  • CD33 antigen (gp67) antibody

  • CD33 antigen antibody
  • CD33 molecule antibody
  • CD33_HUMAN antibody
  • FLJ00391 antibody
  • gp67 antibody
  • My9 antibody
  • Myeloid cell surface antigen CD33 antibody
  • Myeloid cell surface antigen CD33 precursor antibody
  • Myeloid differentiation antigen CD33 antibody
  • p67 antibody
  • Sialic acid binding Ig like lectin 3 antibody
  • Sialic acid binding immunoglobulin like lectin 3 antibody
  • Sialic acid-binding Ig-like lectin 3 antibody
  • SIGLEC 3 antibody
  • Siglec-3 antibody
  • SIGLEC3 antibody

  see all

プロトコール

• Flow cytometry protocols
• Immunoprecipitation protocols
• Immunohistochemistry protocols
• Immunocytochemistry & immunofluorescence protocols
• Western blot protocols