製品の概要

  • 製品名Anti-CD320 antibody
    CD320 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CD320
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    fragment corresponding to C terminal amino acids 255-282 (AQERLRPLGLLVAMKESLLLSEQKTSLP) of Human CD320.

  • ポジティブ・コントロール
    • Human lymph node tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab121433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.
  • 組織特異性Expressed abundantly on follicular dendritic cells (FDCs).
  • 関連疾患Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) [MIM:613646]; also called methylmalonic aciduria due to transcobalamin receptor defect. MMATC is a metabolic disorder characterized by increased blood C3-acylcarnitine levels, elevated methylmalonate and homocysteine, and low uptake of transcobalamin-bound cobalamin, but normal conversion to adenosylcobalamin and methylcobalamin. Plasma vitamin B12 and total homocysteine are normal.
  • 配列類似性Contains 2 LDL-receptor class A domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 8D6 antibody
    • 8D6 antigen antibody
    • 8D6A antibody
    • CD320 antibody
    • CD320 antigen antibody
    • CD320_HUMAN antibody
    • FDC-signaling molecule 8D6 antibody
    • FDC-SM-8D6 antibody
    • TCblR antibody
    • Transcobalamin receptor antibody
    see all

Anti-CD320 antibody 画像

  • ab121433 at a 1/50 dilution staining CD320 in paraffin-embedded Human lymph node tissue by Immunohistochemistry.

Anti-CD320 antibody (ab121433) 使用論文

This product has been referenced in:
  • Fowler R  et al. Uptake and transport of B12-conjugated nanoparticles in airway epithelium. J Control Release 172:374-81 (2013). ICC/IF ; Human . Read more (PubMed: 24008152) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"