特記事項（精製）Affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 23 kDa (predicted molecular weight: 23 kDa).
機能Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
関連疾患Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
配列類似性Belongs to the CD3Z/FCER1G family. Contains 3 ITAM domains.
ドメインThe ITAM domains mediate interaction with SHB.
翻訳後修飾Phosphorylated on Tyr residues after T-cell receptor triggering.