The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報IHC-P: use neat for 10 min at room temperature. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. In particular, boil tissue sections in 10mM citrate buffer pH 6.0 for 10 min and then cool at room temperature for 20 min.
Staining pattern: Cell membrane
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
関連疾患Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
配列類似性Belongs to the CD3Z/FCER1G family. Contains 3 ITAM domains.
ドメインThe ITAM domains mediate interaction with SHB.
翻訳後修飾Phosphorylated on Tyr residues after T-cell receptor triggering.