製品の概要

  • 製品名Anti-CD3 antibody [BB12]
    CD3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [BB12] to CD3
  • 特異性Human T cell CD3 antigen, molecular weight 22-28 kDa.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab1247 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報1. Counting and identification of mature T lymphocytes in human lysed whole peripheral blood or mononuclear cells separated by density gradient.
    2. In combination with other monoclonal antibodies, this antibody may also be useful for thediagnosis of T cell leukaemias and lymphomas.

    CD3 immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.

    10µl ofCD3 is sufficient for labelling of 1x106 cells.
  • ターゲット情報

    • 機能The CD3 complex mediates signal transduction.
    • 関連疾患Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
    • 配列類似性Contains 1 ITAM domain.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
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    Anti-CD3 antibody [BB12] (ab1247) 使用論文

    ab1247 has not yet been referenced specifically in any publications.

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