製品の概要

  • 製品名
    Anti-CD226 antibody [DX11]
    CD226 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [DX11] to CD226
  • アプリケーション
    適用あり: Flow Cyt, Functional Studies, IP, Blockingmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Tissue/ cell preparation (Human) - cytotoxic T lymphocyte clone.

  • 特記事項


    This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
  • 一次抗体 備考
    This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.
  • ポリ/モノ
    モノクローナル
  • クローン名
    DX11
  • ミエローマ
    Sp2/0
  • アイソタイプ
    IgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab33397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 10µl for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration. PubMed: 23980210

ターゲット情報

  • 機能
    Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
  • 組織特異性
    Expressed by peripheral blood T-lymphocytes.
  • 配列類似性
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • adhesion glycoprotein antibody
    • CD226 antibody
    • CD226 antigen antibody
    • CD226 molecule antibody
    • CD226_HUMAN antibody
    • DNAM 1 antibody
    • DNAM-1 antibody
    • DNAM1 antibody
    • DNAX accessory molecule 1 antibody
    • platelet and T cell activation antigen 1 antibody
    • PTA1 antibody
    • T lineage specific activation antigen 1 antigen antibody
    • TLiSA1 antibody
    see all

画像

  • Human peripheral blood lymphocytes stained with ab33397, using 10µl of the working dilution for 106 cells in 100µl.

参考文献

This product has been referenced in:
  • Lozano E  et al. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol 191:3673-80 (2013). Blocking ; Human . Read more (PubMed: 23980210) »
  • Lozano E  et al. The TIGIT/CD226 axis regulates human T cell function. J Immunol 188:3869-75 (2012). Read more (PubMed: 22427644) »

See all 3 Publications for this product

レビューと Q&A

A description of the production and characterization of the CD226 antibody, clone DX11, and the statement regarding inhibition and blocking, are in the following reference.


Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule invol...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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