製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CD20
  • アプリケーション
    適用あり: IHC-Fr, WB, IP, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide from C terminus of human CD20.

  • ポジティブ・コントロール
    • BJAB WCL and tonsil.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab27093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration. PubMed: 19139298
WB Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
IP Use at an assay dependent concentration.
IHC-P 1/300. Antigen retrieval is not essential but may optimise staining.

ターゲット情報

  • 機能
    This protein may be involved in the regulation of B-cell activation and proliferation.
  • 組織特異性
    Expressed on B-cells.
  • 関連疾患
    Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 配列類似性
    Belongs to the MS4A family.
  • 翻訳後修飾
    Phosphorylated. Might be functionally regulated by protein kinase(s).
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • APY antibody
    • ATOPY antibody
    • B lymphocyte antigen CD20 antibody
    • B Lymphocyte Cell Surface Antigen B1 antibody
    • B-lymphocyte antigen CD20 antibody
    • B-lymphocyte cell-surface antigen B1 antibody
    • B-lymphocyte surface antigen B1 antibody
    • B1 antibody
    • Bp 35 antibody
    • Bp35 antibody
    • CD 20 antibody
    • CD20 antibody
    • CD20 antigen antibody
    • CD20 receptor antibody
    • CD20_HUMAN antibody
    • CVID5 antibody
    • Fc epsilon receptor I beta chain antibody
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody
    • FCER1B antibody
    • High affinity immunoglobulin epsilon receptor subunit beta antibody
    • IgE Fc receptor subunit beta antibody
    • IGEL antibody
    • IGER antibody
    • IGHER antibody
    • LEU 16 antibody
    • LEU16 antibody
    • leukocyte surface antigen Leu 16 antibody
    • Leukocyte surface antigen Leu-16 antibody
    • Ly44 antibody
    • Membrane spanning 4 domains A1 antibody
    • Membrane spanning 4 domains subfamily A member 2 antibody
    • Membrane-spanning 4-domains subfamily A member 1 antibody
    • MGC3969 antibody
    • MS4A1 antibody
    • MS4A2 antibody
    • S7 antibody
    see all

画像

  • Formalin fixed, paraffin embedded human tonsil tissue slide stained with anti CD20 antibody (ab27093).
  • Anti-CD20 antibody (ab27093) at 1/25 dilution + Raji cell lysate

    Predicted band size : 33 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)

参考文献

This product has been referenced in:
  • Miles B  et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog 12:e1005924 (2016). IHC (PFA fixed) ; Rhesus monkey . Read more (PubMed: 27716848) »
  • Miles B  et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun 6:8608 (2015). Read more (PubMed: 26482032) »

See all 5 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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