Anti-CD20 抗体 [2H7] (ab111274)


  • 製品名
    Anti-CD20 antibody [2H7]
    CD20 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2H7] to CD20
  • アプリケーション
    適用あり: IP, IHC-Fr, Flow Cytmore details
  • 種交差性
    交差種: Human, Non human primates
  • 免疫原

    Human tonsillar B cells

  • エピトープ
    The epitope recognised by this antibody has been mapped to the following sequence which is found in the large extracellular loop of human CD20: YNCEPANPSEKNSPST



Our Abpromise guarantee covers the use of ab111274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use a concentration of 0.6 µg/ml. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.


  • 機能
    This protein may be involved in the regulation of B-cell activation and proliferation.
  • 組織特異性
    Expressed on B-cells.
  • 関連疾患
    Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 配列類似性
    Belongs to the MS4A family.
  • 翻訳後修飾
    Phosphorylated. Might be functionally regulated by protein kinase(s).
  • 細胞内局在
  • Information by UniProt
  • 参照データベース
  • 別名
    • APY antibody
    • ATOPY antibody
    • B lymphocyte antigen CD20 antibody
    • B Lymphocyte Cell Surface Antigen B1 antibody
    • B-lymphocyte antigen CD20 antibody
    • B-lymphocyte cell-surface antigen B1 antibody
    • B-lymphocyte surface antigen B1 antibody
    • B1 antibody
    • Bp 35 antibody
    • Bp35 antibody
    • CD 20 antibody
    • CD20 antibody
    • CD20 antigen antibody
    • CD20 receptor antibody
    • CD20_HUMAN antibody
    • CVID5 antibody
    • Fc epsilon receptor I beta chain antibody
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody
    • FCER1B antibody
    • High affinity immunoglobulin epsilon receptor subunit beta antibody
    • IgE Fc receptor subunit beta antibody
    • IGEL antibody
    • IGER antibody
    • IGHER antibody
    • LEU 16 antibody
    • LEU16 antibody
    • leukocyte surface antigen Leu 16 antibody
    • Leukocyte surface antigen Leu-16 antibody
    • Ly44 antibody
    • Membrane spanning 4 domains A1 antibody
    • Membrane spanning 4 domains subfamily A member 2 antibody
    • Membrane-spanning 4-domains subfamily A member 1 antibody
    • MS4A1 antibody
    • MS4A2 antibody
    • S7 antibody
    see all

Anti-CD20 antibody [2H7] (ab111274) 使用論文

ab111274 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Immunohistochemistry free floating
Human Tissue sections (Human B cells Lymphoma xenografted in rat tissue)
Human B cells Lymphoma xenografted in rat tissue

Fabien Fillesoye

Verified customer

投稿 Oct 21 2016

The 2H7 clone is not the same as the rituxan antibody and does not recognize the exact same epitope. I found an article that discusses in detail the differences between the two antibodies.

Crystal structure of chimeric antibody C2H7 Fab in com...

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Thank you for contacting us.

Unfortunately we have not performed any kind of cytotoxicity assays with these antibodies. I was however able to find a paper referring to these assays with a murine monoclonal antibody anti CD20 from clone [B-Ly1...

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