製品の概要

  • 製品名
    Anti-CD19 antibody [6D5] (PE/Cy5®)
    CD19 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [6D5] to CD19 (PE/Cy5®)
  • 標識
    PE/Cy5®. Ex: 496nm, Em: 670nm
  • 特異性
    CD19 B-cell differentiation antigen
  • アプリケーション
    適用あり: Flow Cyt, IP, Functional Studiesmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Mouse CD19-expressing K562 human erythroleukemia cells

  • 特記事項
    This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5,268,486 and related patents. Cy and CyDye are trademarks of GE Healthcare Limited.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab25508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
IP
Functional Studies
  • 追加情報
    Flow Cyt: Use 0.2µg for 106 cells.
    IP: Use at an assay dependent dilution.
    In vivo and in vitro functional studies:Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    • 関連疾患
      Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 配列類似性
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻訳後修飾
      Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
    • 細胞内局在
      Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Antibody deficiency due to defect in CD19, included antibody
      • AW495831 antibody
      • B lymphocyte antigen CD19 antibody
      • B lymphocyte surface antigen B4 antibody
      • B-lymphocyte antigen CD19 antibody
      • B-lymphocyte surface antigen B4 antibody
      • B4 antibody
      • CD19 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Cd19 protein antibody
      • CD19_HUMAN antibody
      • CVID3 antibody
      • Differentiation antigen CD19 antibody
      • Leu 12 antibody
      • Leu-12 antibody
      • Leu12 antibody
      • MGC109570 antibody
      • MGC12802 antibody
      • T-cell surface antigen Leu-12 antibody
      see all

    画像

    • Flow cytometric analysis of C57BL/6 mouse splenocytes labelling CD19 with ab25508 at 0.01 μg/106 cells and labelling CD4 with a Rat Anti-Mouse CD4-PE antibody (ab25496).

    参考文献

    This product has been referenced in:

    See all 3 Publications for this product

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab25508.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録