製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab34324 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 103 kDa.
Inhibition Assay Use at an assay dependent concentration. This antibody has been shown to inhibit OSM (oncostatin M) and LIF (leukemia inhibitory factor) activity, as well as OSM binding.

ターゲット情報

  • 機能Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
  • 組織特異性Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
  • 配列類似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • ドメインThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻訳後修飾Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD130 antibody
    • CD130 antigen antibody
    • CDw130 antibody
    • gp130 antibody
    • GP130 RAPS antibody
    • IL 6R beta antibody
    • IL-6 receptor subunit beta antibody
    • IL-6R subunit beta antibody
    • IL-6R-beta antibody
    • IL-6RB antibody
    • IL6 ST antibody
    • IL6RB_HUMAN antibody
    • IL6ST antibody
    • Interleukin 6 receptor subunit beta antibody
    • Interleukin receptor beta chain antibody
    • Interleukin-6 receptor subunit beta antibody
    • Interleukin-6 signal transducer antibody
    • Membrane glycoprotein 130 antibody
    • Membrane glycoprotein gp130 antibody
    • Oncostatin M receptor antibody
    • Oncostatin M receptor alpha subunit antibody
    • Oncostatin-M receptor subunit alpha antibody
    see all

Anti-CD130 (gp130) antibody [B-K5] (ab34324) 使用論文

This product has been referenced in:
  • Chevalier S  et al. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. J Biol Chem 271:14764-72 (1996). Read more (PubMed: 8662918) »

See 1 Publication for this product

Product Wall

Vielen Dank fuer Ihre Rueckmeldung. Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab27357 im Inhibitionsassay zu testen, annehmen möchten. DISCOUNT CODE: xxx Ablaufdatum: dd.mm.2012 Wie am Telefon besprochen, können Sie den ...

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Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten. Wie am Telefon besprochen, kann ich Ihnen für den CD130- Antikörperklon [B-P4] ab27357 das Testangebot machen, falls Sie den Inhibitionsassay austesten möchten (Details siehe un...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"