Anti-CD130 (gp130) 抗体 (ab14492)

製品の概要

• 製品名
  Anti-CD130 (gp130) antibody
  CD130 (gp130) 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to CD130 (gp130)
• 特異性
  Detects total endogenous levels of GP130 protein independent of phosphorylation.
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide (Human) conjugated to KLH (N terminal). (The exact sequence is proprietary)

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: None
  Constituents: 50% Glycerol, BSA, 150mM Sodium Chloride, 10mM HEPES. pH 7.5
• Concentration information loading...
• 精製度
  Protein A purified
• 特記事項（精製）
  Purified by protein A and peptide affinity chromatography.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Intracellular
  • Associated Proteins

  • Immunology
  • Cell Type Markers
  • CD
  • Cytokines

  • Signal Transduction
  • Adapters
  • Transmembrane

  • Cancer
  • Signal transduction
  • Other

  • Cardiovascular
  • Atherosclerosis
  • Apoptosis

  • Cardiovascular
  • Heart
  • Apoptosis

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
• 組織特異性
  Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
• 配列類似性
  Belongs to the type I cytokine receptor family. Type 2 subfamily.
  Contains 5 fibronectin type-III domains.
  Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
• ドメイン
  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  The box 1 motif is required for JAK interaction and/or activation.
• 翻訳後修飾
  Phosphorylation of Ser-782 down-regulates cell surface expression.
  Heavily N-glycosylated.
• 細胞内局在
  Secreted and Cell membrane.

• Target information above from: UniProt accession P40189 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 3572 Human
  • Omim: 600694 Human
  • SwissProt: P40189 Human
  • Unigene: 532082 Human
  • Unigene: 706627 Human
• 別名
  • CD130 antibody
  • CD130 antigen antibody
  • CDw130 antibody

  • gp130 antibody
  • GP130 RAPS antibody
  • IL 6R beta antibody
  • IL-6 receptor subunit beta antibody
  • IL-6R subunit beta antibody
  • IL-6R-beta antibody
  • IL-6RB antibody
  • IL6 ST antibody
  • IL6RB_HUMAN antibody
  • IL6ST antibody
  • Interleukin 6 receptor subunit beta antibody
  • Interleukin receptor beta chain antibody
  • Interleukin-6 receptor subunit beta antibody
  • Interleukin-6 signal transducer antibody
  • Membrane glycoprotein 130 antibody
  • Membrane glycoprotein gp130 antibody
  • Oncostatin M receptor antibody
  • Oncostatin M receptor alpha subunit antibody
  • Oncostatin-M receptor subunit alpha antibody

  see all

プロトコール

• Western blot protocols