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機能
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
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組織特異性
Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
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配列類似性
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
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ドメイン
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
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翻訳後修飾
Phosphorylation of Ser-782 down-regulates cell surface expression.
Heavily N-glycosylated.
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細胞内局在
Secreted and Cell membrane.
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Information by UniProt
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参照データベース
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別名
- CD130 antibody
- CD130 antigen antibody
- CDw130 antibody
- gp130 antibody
- GP130 RAPS antibody
- IL 6R beta antibody
- IL-6 receptor subunit beta antibody
- IL-6R subunit beta antibody
- IL-6R-beta antibody
- IL-6RB antibody
- IL6 ST antibody
- IL6RB_HUMAN antibody
- IL6ST antibody
- Interleukin 6 receptor subunit beta antibody
- Interleukin receptor beta chain antibody
- Interleukin-6 receptor subunit beta antibody
- Interleukin-6 signal transducer antibody
- Membrane glycoprotein 130 antibody
- Membrane glycoprotein gp130 antibody
- Oncostatin M receptor antibody
- Oncostatin M receptor alpha subunit antibody
- Oncostatin-M receptor subunit alpha antibody
see all