Anti-CD11b/c 抗体 [OX42] (Biotin) (ab33827)

製品の概要

  • 製品名
    Anti-CD11b/c antibody [OX42] (Biotin)
    CD11b/c 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [OX42] to CD11b/c (Biotin)
  • 標識
    Biotin
  • アプリケーション
    適用あり: Flow Cyt, IHC-Fr, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Rat peritoneal macrophages

  • ポジティブ・コントロール
    • Rat peritoneal macrophages
  • 特記事項


    ab33827 recognises CD11b expressed on most macrophages, including resident and activated peritoneal macrophages, Kupffer cells, around 35% of alveolar macrophages, dendritic cells, granulocytes and microglial cells in the brain.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab33827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 10µl for 106 cells.

Use neat - 1/10. Use 10µl of the suggested working dilution to label 106 cells in 100µl.





ab18418-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Samples need to be PLP (periodate-lysine-paraformaldehyde) fixed.

ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
  • 組織特異性
    Predominantly expressed in monocytes and granulocytes.
  • 関連疾患
    Systemic lupus erythematosus 6
  • 配列類似性
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • ドメイン
    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Antigen CD11b (p170) antibody
    • CD11 antigen like family member B antibody
    • CD11 antigen like family member C antibody
    • CD11 antigen-like family member B antibody
    • CD11b antibody
    • CD11C antibody
    • Cell surface glycoprotein MAC 1 subunit alpha antibody
    • Cell surface glycoprotein MAC-1 subunit alpha antibody
    • CR 3 alpha chain antibody
    • CR-3 alpha chain antibody
    • CR3A antibody
    • Integrin alpha M antibody
    • Integrin alpha X antibody
    • Integrin alpha-M antibody
    • Integrin, alpha M (complement component 3 receptor 3 subunit) antibody
    • Integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody
    • Integrin, alpha X (complement component 3 receptor 4 subunit) antibody
    • ITAM_HUMAN antibody
    • ITGAM antibody
    • ITGAX antibody
    • Leu M5, alpha subunit antibody
    • Leukocyte adhesion glycoprotein p150,95 alpha chain antibody
    • Leukocyte adhesion receptor MO1 antibody
    • Leukocyte adhesion receptor p150,95 antibody
    • Leukocyte surface antigen p150,95, alpha subunit antibody
    • MAC 1 antibody
    • MAC1A antibody
    • Macrophage antigen alpha polypeptide antibody
    • MGC117044 antibody
    • MO1A antibody
    • Myeloid membrane antigen, alpha subunit antibody
    • Neutrophil adherence receptor alpha M subunit antibody
    • Neutrophil adherence receptor antibody
    • OTTHUMP00000163299 antibody
    • p150 95 integrin alpha chain antibody
    • SLEB6 antibody
    see all

Anti-CD11b/c antibody [OX42] (Biotin) 画像

  • FACS analysis of rat peritoneal macrophages using ab33827.

Anti-CD11b/c antibody [OX42] (Biotin) (ab33827) 使用論文

ab33827 has not yet been referenced specifically in any publications.

Product Wall

Yes, a biotin-conjugated Ab can be readily detected via streptavidin conjugated to HRP. The biotin-streptavidin interaction is very specific and of very high affinity.

One option for a ready-to-use streptavidin-peroxidase product can be fou...

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The following references report use of Ab clone OX42 in fluorescent staining applications:
Stidworthy MF, et al. Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Brain....

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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