Anti-CD11a 抗体 [M17/4] (ab119878)
Key features and details
- Rat monoclonal [M17/4] to CD11a
- Suitable for: Blocking, IP, Functional Studies, IHC-Fr, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
Related conjugates and formulations
製品の概要
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製品名
Anti-CD11a antibody [M17/4]
CD11a 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [M17/4] to CD11a -
由来種
Rat -
アプリケーション
適用あり: Blocking, IP, Functional Studies, IHC-Fr, Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse CD11a. C57BL/6 Mouse splenic secondary cytotoxic T lymphocytes.
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ポジティブ・コントロール
- Mouse spleen or thymus tissues
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted. -
バッファー
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
M17/4 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab119878の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Blocking |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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Functional Studies |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
Application note: acetone fixation. |
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Flow Cyt |
Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
特記事項 |
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Blocking
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. Application note: acetone fixation. |
Flow Cyt
Use at an assay dependent concentration. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. -
組織特異性
Leukocytes. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16408 Mouse
- SwissProt: P24063 Mouse
- Unigene: 1618 Mouse
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別名
- Lymphocyte function associated antigen, type 1, alpha subunit antibody
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- Antigen CD11A antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab119878 は 4 報の論文で使用されています。
- Angelov GS et al. Soluble MHC-peptide complexes containing long rigid linkers abolish CTL-mediated cytotoxicity. J Immunol 176:3356-65 (2006). PubMed: 16517703
- Beyer M et al. The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir Res 6:70 (2005). PubMed: 16011799
- Bellingan GJ et al. Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med 196:1515-21 (2002). PubMed: 12461086
- Papayannopoulou T et al. Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice. Blood 97:1282-8 (2001). PubMed: 11222371