CF405M Anti-CD105 抗体 [2H6F11], prediluted (ab123634)
Key features and details
- CF405M Mouse monoclonal [2H6F11] to CD105, prediluted
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: CF405M. Ex: 408nm, Em: 452nm
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
CF405M Anti-CD105 antibody [2H6F11], prediluted
CD105 一次抗体 製品一覧 -
製品の詳細
CF405M Mouse monoclonal [2H6F11] to CD105, prediluted -
由来種
Mouse -
標識
CF405M. Ex: 408nm, Em: 452nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to CD105. Human Endoglin fusion protein.
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ポジティブ・コントロール
- Nalm-6 cell line
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特記事項
CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.
CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide -
Concentration information loading...
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精製度
Immunogen affinity purified -
一次抗体 備考
CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation. -
ポリ/モノ
モノクローナル -
クローン名
2H6F11 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab123634の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
Use 5µl for 106 cells.
ab126026 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
特記事項 |
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Flow Cyt
Use 5µl for 106 cells. ab126026 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. -
組織特異性
Endoglin is restricted to endothelial cells in all tissues except bone marrow. -
関連疾患
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2022 Human
- Omim: 131195 Human
- SwissProt: P17813 Human
- Unigene: 76753 Human
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別名
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab123634 は論文での使用が確認できていません。