製品の概要

  • 製品名Anti-CCRL2 antibody
    CCRL2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CCRL2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rabbit, Horse, Guinea pig, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (LSAQLVPSLC SAVFVIGVLD NLLVVLILVK YKGLKRVENI YLLNLAVSNL) of Human CCRL2 (NP_003956).

  • ポジティブ・コントロール
    • 721_B Cell Lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab85224 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 40 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
  • 組織特異性Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
  • 配列類似性Belongs to the G-protein coupled receptor 1 family.
  • ドメインLacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C-C chemokine receptor-like 2 antibody
    • CCRL2 antibody
    • CCRL2_HUMAN antibody
    • Chemokine (C-C motif) receptor like 2 antibody
    • Chemokine receptor CCR11 antibody
    • Chemokine receptor X antibody
    • CKRX antibody
    • CRAM A antibody
    • CRAM B antibody
    • CRAMA antibody
    • CRAMB antibody
    • FLJ55815 antibody
    • HCR antibody
    • MGC116710 antibody
    • MGC34104 antibody
    • Putative MCP 1 chemokine receptor antibody
    • Putative MCP-1 chemokine receptor antibody
    see all

Anti-CCRL2 antibody 画像

  • Anti-CCRL2 antibody (ab85224) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B Cell Lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 40 kDa
    Observed band size : ~39 kDa (why is the actual band size different from the predicted?)
    Additional bands at : ~70 kDa. We are unsure as to the identity of these extra bands.

Anti-CCRL2 antibody (ab85224) 使用論文

ab85224 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"