製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to CCNDBP1
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog, Orangutan
  • 免疫原

    Synthetic peptide:

    C-NRIKELTQSELEL

    , corresponding to C terminal amino acids 348-360 of Human CCNDBP1.

  • ポジティブ・コントロール
    • Human Brain cortex and Human prostate tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
  • 組織特異性
    Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
  • 配列類似性
    Belongs to the CCNDBP1 family.
  • 発生段階
    Expression may increase during differentiation.
  • 翻訳後修飾
    Phosphorylated.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AU022347 antibody
    • CCDB1_HUMAN antibody
    • CCNDBP 1 antibody
    • Ccndbp1 antibody
    • Cyclin D type binding protein 1 antibody
    • Cyclin-D1-binding protein 1 antibody
    • D type cyclin interacting protein 1 antibody
    • DIP 1 antibody
    • DIP1 antibody
    • GCIP antibody
    • Grap 2 and cyclin D interacting protein antibody
    • Grap 2 cyclin D interacting protein GCIP antibody
    • Grap 2 cyclin interacting protein antibody
    • Grap2 and cyclin D interacting protein antibody
    • Grap2 and cyclin-D-interacting protein antibody
    • Grap2 cyclin D interacting protein GCIP antibody
    • Grap2 cyclin interacting protein antibody
    • HHM antibody
    • HHM protein antibody
    • Human homolog of Maid antibody
    • MAID antibody
    • MAID protein antibody
    • Maternal inhibition of differentiation antibody
    • MGC109078 antibody
    • OTTMUSP00000017037 antibody
    • RP23 263D22.2 antibody
    • SECC 8 antibody
    • SSEC 8 antibody
    • Stage specific embryonic cDNA 8 antibody
    see all

画像

  • ab110868 at 3.75 µg/ml staining CCNDBP1 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry.
  • ab110868 at 3.75 µg/ml staining CCNDBP1 in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.

プロトコール

参考文献

ab110868 has not yet been referenced specifically in any publications.

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