製品の概要

  • 製品名Anti-CCM2 antibody
    CCM2 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to CCM2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human CCM2 protein (NP_113631.1).

  • ポジティブ・コントロール
    • Human placenta tissue lysate. Cell lysate from transfected 293T cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 49 kDa.

ターゲット情報

  • 機能May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • 関連疾患Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • 配列類似性Contains 1 PID domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C7orf22 antibody
    • Ccm2 antibody
    • CCM2 gene antibody
    • CCM2_HUMAN antibody
    • Cerebral cavernous malformation 2 antibody
    • Cerebral cavernous malformations 2 protein antibody
    • Chromosome 7 open reading frame 22 antibody
    • Malcavernin antibody
    • MGC4067 antibody
    • MGC4607 antibody
    • MGC74868 antibody
    • OSM antibody
    • Osmosensing scaffold for MEKK3 antibody
    • OTTHUMP00000159554 antibody
    • OTTHUMP00000214270 antibody
    • OTTHUMP00000214271 antibody
    • OTTHUMP00000214273 antibody
    • PP10187 antibody
    see all

Anti-CCM2 antibody 画像

  • Anti-CCM2 antibody (ab88834) at 1/500 dilution + Human placenta tissue lysate at 50 µg

    Predicted band size : 49 kDa
    Observed band size : 49 kDa
  • All lanes : Anti-CCM2 antibody (ab88834) at 1/500 dilution

    Lane 1 : cell lysate from CCM2 transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 49 kDa
    Observed band size : ~65 kDa (why is the actual band size different from the predicted?)

Anti-CCM2 antibody (ab88834) 使用論文

ab88834 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"