製品の概要

  • 製品名Anti-CCM2 antibody
    CCM2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to CCM2
  • 特異性This antibody is expected to recognize both reported isoforms (NP_001025006.1 and NP_113631.1).
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-KGEKSRDKKAHEK

    , corresponding to internal sequence amino acids 23-35 of Human CCM2

  • ポジティブ・コントロール
    • Human heart lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab53557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報Peptide ELISA: antibody detection limit dilution 1:128,000.

    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
    • 関連疾患Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
    • 配列類似性Contains 1 PID domain.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • C7orf22 antibody
      • Ccm2 antibody
      • CCM2 gene antibody
      • CCM2_HUMAN antibody
      • Cerebral cavernous malformation 2 antibody
      • Cerebral cavernous malformations 2 protein antibody
      • Chromosome 7 open reading frame 22 antibody
      • Malcavernin antibody
      • MGC4067 antibody
      • MGC4607 antibody
      • MGC74868 antibody
      • OSM antibody
      • Osmosensing scaffold for MEKK3 antibody
      • OTTHUMP00000159554 antibody
      • OTTHUMP00000214270 antibody
      • OTTHUMP00000214271 antibody
      • OTTHUMP00000214273 antibody
      • PP10187 antibody
      see all

    Anti-CCM2 antibody 画像

    • Anti-CCM2 antibody (ab53557) at 0.03 µg/ml + Human Heart lysate (35µg protein in RIPA buffer)

      Predicted band size : 49 kDa
      Observed band size : 49 kDa

    Anti-CCM2 antibody (ab53557) 使用論文

    ab53557 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab53557.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"