製品の概要

  • 製品名Anti-CCKBR antibody
    CCKBR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CCKBR
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human, African Green Monkey
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    A synthesized peptide derived from the internal region of human CCKBR.

  • ポジティブ・コントロール
    • Extracts from COS-7 cells, A549 cells and K562 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/20000.
    WB: 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
      Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
    • 組織特異性Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
    • 配列類似性Belongs to the G-protein coupled receptor 1 family.
    • 細胞内局在Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CCK B antibody
      • CCK B receptor antibody
      • CCK BR antibody
      • CCK-B receptor antibody
      • CCK-BR antibody
      • CCK2 R antibody
      • CCK2 receptor antibody
      • CCK2-R antibody
      • CCKB antibody
      • CCKB receptor antibody
      • CCKBR antibody
      • CCKR Type B antibody
      • CCKRB antibody
      • Cholecystokinin 2 receptor antibody
      • Cholecystokinin B receptor antibody
      • Cholecystokinin-2 receptor antibody
      • Cholecystokinin2 receptor antibody
      • CholecystokininB receptor antibody
      • GASR antibody
      • GASR_HUMAN antibody
      • Gastrin receptor antibody
      • Gastrin/cholecystokinin type B receptor antibody
      • Gastrin\cholecystokinin brain receptor antibody
      see all

    Anti-CCKBR antibody 画像

    • All lanes : Anti-CCKBR antibody (ab76250) at 1/500 dilution

      Lane 1 : Extracts from COS-7 cells
      Lane 2 : Extracts from A549 cells
      Lane 3 : Extracts from K562 cells
      Lane 4 : Extracts from K562 cells plus 5µg immunizing peptide

      Lysates/proteins at 5 µg per lane.


      Predicted band size : 48 kDa
      Observed band size : 48 kDa

    Anti-CCKBR antibody (ab76250) 使用論文

    ab76250 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76250.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"