製品の概要

  • 製品名Anti-CCDC98 antibody
    CCDC98 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CCDC98
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Chicken, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human CCDC98.

    (Peptide available as ab74341.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following Tissue Lysates: Mouse Pancreas, Human Testis

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab64272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 52 kDa (predicted molecular weight: 47 kDa).

ターゲット情報

  • 機能Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
  • 配列類似性Belongs to the FAM175 family. Abraxas subfamily.
  • ドメインThe MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
  • 翻訳後修飾Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus. Localizes at sites of DNA damage at double-strand breaks.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3830405G04Rik antibody
    • 5630400M01Rik antibody
    • ABRA1 antibody
    • ABRAXAS antibody
    • Abraxas protein antibody
    • AI506069 antibody
    • AL024423 antibody
    • AV118690 antibody
    • BRCA1-A complex subunit Abraxas antibody
    • coiled coil domain containing 98 antibody
    • Coiled-coil domain-containing protein 98 antibody
    • F175A_HUMAN antibody
    • FAM175A antibody
    • Family with sequence similarity 175 member A antibody
    • FLJ11520 antibody
    • FLJ12642 antibody
    • FLJ13614 antibody
    • Protein FAM175A antibody
    see all

Anti-CCDC98 antibody 画像

  • All lanes : Anti-CCDC98 antibody (ab64272) at 1 µg/ml

    Lane 1 : Pancreas (Mouse) Tissue Lysate
    Lane 2 : Human testis tissue lysate - total protein (ab30257)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 47 kDa
    Observed band size : 52 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 90 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 10 minutes

Anti-CCDC98 antibody (ab64272) 使用論文

ab64272 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"