製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to CCDC50
  • 特異性
    This antibody is expected to recognise both reported isoforms of human CCDC50 protein.
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Chimpanzee
  • 免疫原

    Synthetic peptide:

    (C)FSKSESSHKGFHYK

    , corresponding to C terminal amino acids 292-305 of Human CCDC50

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab32884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: Use at a concentration of 5 µg/ml.
    This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Involved in EGFR signaling.
    • 組織特異性
      Isoform 1 and isoform 2 are co-expressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart.
    • 関連疾患
      Defects in CCDC50 are the cause of deafness autosomal dominant type 44 (DFNA44) [MIM:607453]. A form of non-syndromic hearing loss. It is initially moderate and affects mainly low to mid frequencies. Later, it progresses to involve all the frequencies and leads to a profound hearing loss by the 6th decade. The onset of the hearing loss occurs in the first decade of life.
    • 翻訳後修飾
      Phosphorylated on tyrosine residues.
    • 細胞内局在
      Cytoplasm. Associated with microtubules of the cytoskeleton and mitotic apparatus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • C3orf6 antibody
      • C3orf6 YMER antibody
      • CCD50_HUMAN antibody
      • CCDC 50 antibody
      • Ccdc50 antibody
      • Chromosome 3 open reading frame 6 antibody
      • Coiled coil domain containing 50 antibody
      • Coiled coil domain containing protein 50 antibody
      • Coiled-coil domain-containing protein 50 antibody
      • Protein Ymer antibody
      • Ymer antibody
      • Ymer protein antibody
      see all

    画像

    • ab32884 at 5ug/ml staining CCDC50 in human pancreas tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). A AP-staining procedure was used for detection.

    プロトコール

    参考文献

    ab32884 has not yet been referenced specifically in any publications.

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