The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: 1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight for isoform 3: 23 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
組織特異性Not expressed in blood or lymphatic endothelial cells.
関連疾患Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLYLMP) [MIM:235510]. HLYLMP is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.
配列類似性Belongs to the CCBE1 family. Contains 2 collagen-like domains. Contains 1 EGF-like domain.