製品の概要

  • 製品名Anti-CBS antibody
    CBS 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to CBS
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-551 of Human CBS (NP_000062.1).

  • ポジティブ・コントロール
    • Human liver tissue lysate and lysate from CBS transfected 293T cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88437 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 61 kDa.

ターゲット情報

  • 機能Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
  • 組織特異性In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
  • パスウェイAmino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.
  • 関連疾患Defects in CBS are the cause of cystathionine beta-synthase deficiency (CBSD) [MIM:236200]. CBSD is an enzymatic deficiency resulting in altered sulfur metabolism and homocystinuria. The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Light skin and hair can also be present. Biochemical features include increased urinary homocystine and methionine.
  • 配列類似性Belongs to the cysteine synthase/cystathionine beta-synthase family.
    Contains 1 CBS domain.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI047524 antibody
    • AI303044 antibody
    • Beta thionase antibody
    • Beta-thionase antibody
    • Cbs antibody
    • Cbs cystathionine beta-synthase antibody
    • CBS_HUMAN antibody
    • Cystathionine beta synthase antibody
    • Cystathionine beta-synthase antibody
    • EC 4.2.1.22 antibody
    • HIP 4 antibody
    • HIP4 antibody
    • Methylcysteine synthase antibody
    • MGC18856 antibody
    • MGC18895 antibody
    • MGC37300 antibody
    • OTTHUMP00000109416 antibody
    • OTTHUMP00000109418 antibody
    • Serine sulfhydrase antibody
    see all

Anti-CBS antibody 画像

  • Anti-CBS antibody (ab88437) at 1 µg/ml + human liver tissue lysate at 25 µg
    Developed using the ECL technique

    Predicted band size : 61 kDa
    Observed band size : 61 kDa
  • All lanes : Anti-CBS antibody (ab88437) at 1 µg/ml

    Lane 1 : cell lysate from CBS transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.

    Developed using the ECL technique

    Predicted band size : 61 kDa
    Observed band size : 61 kDa

Anti-CBS antibody (ab88437) 使用論文

ab88437 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88437.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"