製品の概要

  • 製品名Anti-CBLN1 antibody
    CBLN1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to CBLN1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human CBLN1 (internal sequence). A 15 amino acid synthetic peptide from the middle of human CBLN1.

  • ポジティブ・コントロール
    • Human prostate tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab64184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.
    The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
  • 組織特異性In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • 配列類似性Contains 1 C1q domain.
  • 発生段階Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.
  • 翻訳後修飾The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.
  • 細胞内局在Secreted. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • [des-Ser1]-cerebellin antibody
    • CBLN 1 antibody
    • CBLN1 antibody
    • CBLN1_HUMAN antibody
    • CER antibody
    • Cerebellin 1 antibody
    • Cerebellin 1 precursor antibody
    • Cerebellin1 antibody
    • Precerebellin antibody
    see all

Anti-CBLN1 antibody 画像

  • ab64184 (10ug/ml) staining human CBLN1 in human prostate tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-CBLN1 antibody (ab64184) 使用論文

This product has been referenced in:
  • Muguruma K  et al. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci 13:1171-80 (2010). Mouse . Read more (PubMed: 20835252) »

See 1 Publication for this product

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In answer to your questions:

1. Regarding ab36909 Precerebellin antibody

Based on the immunogen sequence, this antibody should detect precerebellin and cerebellin-1 (precerebellin without the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"