Anti-CBL (phospho Y774) 抗体 [E160] (ab32446)

製品の概要

• 製品名
  Anti-CBL (phospho Y774) antibody [E160]
  CBL 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [E160] to CBL (phospho Y774)
• 特異性
  The antibody detects Cbl phosphorylated on Tyrosine 774.
• アプリケーション
  適用あり: WB, IHC-P, ICC/IF, Flow Cyt, IPmore details
• 種交差性
  交差種: Human
  
• 免疫原

  A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human Cbl.

• ポジティブ･コントロール
  • Jurkat cell lysate and human cervical carcinoma tissue.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• ポリ/モノ
  モノクローナル
• クローン名
  E160
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E3 Enzymes
  • RING Finger E3 Ligase

  • Signal Transduction
  • Adapters
  • Cytoplasmic

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Proto-oncogenes

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Co-activators/co-repressors

  • Cancer
  • Signal transduction
  • Nuclear signaling
  • Nuclear hormone receptors
  • Coactivators and repressors

  • Cancer
  • Oncoproteins/suppressors
  • Oncoproteins
  • Other

関連製品

• Positive Controls
  • Jurkat whole cell lysate (ab7899)

アプリケーション

ターゲット情報

• 機能
  Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
• パスウェイ
  Protein modification; protein ubiquitination.
• 関連疾患
  Defects in CBL are the cause of Noonan syndrome-like disorder (NSL) [MIM:613563]. NSL is a syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects.
• 配列類似性
  Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
  Contains 1 RING-type zinc finger.
  Contains 1 UBA domain.
• ドメイン
  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
• 翻訳後修飾
  Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.
• 細胞内局在
  Cytoplasm.

• Target information above from: UniProt accession P22681 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 867 Human
  • Omim: 165360 Human
  • SwissProt: P22681 Human
  • Unigene: 504096 Human
• 別名
  • 4732447J05Rik antibody
  • C CBL antibody
  • Cas Br M (murine) ecotropic retroviral transforming sequence antibody

  • Casitas B lineage lymphoma proto oncogene antibody
  • Casitas B-lineage lymphoma proto-oncogene antibody
  • CBL 2 antibody
  • cbl antibody
  • CBL_HUMAN antibody
  • CBL2 antibody
  • E3 ubiquitin protein ligase CBL antibody
  • E3 ubiquitin-protein ligase CBL antibody
  • Oncogene CBL2 antibody
  • Proto oncogene c CBL antibody
  • Proto-oncogene c-CBL antibody
  • RGD1561386 antibody
  • RING finger protein 55 antibody
  • RNF55 antibody
  • Signal transduction protein CBL antibody

  see all