製品の概要

  • 製品名Anti-CBFb antibody [EPR6321]
    CBFb 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR6321] to CBFb
  • アプリケーション適用あり: WB, ICCmore details
    適用なし: Flow Cyt,IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to residues from Human CBFb.

  • ポジティブ・コントロール
    • K562, Jurkat and HUVEC cell lysates.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 解離定数(KD 値) KD = 1.97 x 10 -10 M Learn more about KD
  • バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名EPR6321
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
ICC 1/100 - 1/250.
  • 追加情報Is unsuitable for Flow Cyt,IHC-P or IP.
  • ターゲット情報

    • 機能CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
    • 関連疾患Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
    • 配列類似性Belongs to the CBF-beta family.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CBF b antibody
      • CBF beta antibody
      • CBF-beta antibody
      • CBFB antibody
      • CBFbeta antibody
      • Core binding factor beta subunit antibody
      • core binding factor subunit beta antibody
      • Core-binding factor subunit beta antibody
      • PEA 2 antibody
      • PEA2 antibody
      • PEA2 beta antibody
      • PEA2-beta antibody
      • PEA2beta antibody
      • PEBB_HUMAN antibody
      • PEBP 2B antibody
      • PEBP2 beta antibody
      • PEBP2-beta antibody
      • PEBP2B antibody
      • PEBP2beta antibody
      • Polyomavirus enhancer binding protein 2 beta subunit antibody
      • Polyomavirus enhancer-binding protein 2 beta subunit antibody
      • SL3 3 enhancer factor 1 beta subunit antibody
      • SL3 3 enhancer factor 1 subunit beta antibody
      • SL3-3 enhancer factor 1 subunit beta antibody
      • SL3/AKV core binding factor beta subunit antibody
      • SL3/AKV core-binding factor beta subunit antibody
      see all

    Anti-CBFb antibody [EPR6321] 画像

    • All lanes : Anti-CBFb antibody [EPR6321] (ab124693) at 1/1000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HUVEC cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 22 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-CBFb antibody [EPR6321] (ab124693) 使用論文

    ab124693 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124693.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"