製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • アクセッション番号Q9WVC3
    • 生物種Mouse
    • 配列MGLETEKADVQLFMADDAYC
    • 領域1 to 19

関連製品

特性

Our Abpromise guarantee covers the use of ab4929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • 備考

     

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous caveolin-2, catalog ab2911. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • CAV
    • CAV2
    • CAV2_HUMAN
    • Caveolae protein 20 kD
    • Caveolin 2
    • Caveolin 2 isoform a and b
    • Caveolin-2
    • MGC12294
    • OTTHUMP00000025032
    • OTTHUMP00000195982
    see all
  • 機能May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
  • 組織特異性Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
  • 配列類似性Belongs to the caveolin family.
  • 翻訳後修飾Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
  • 細胞内局在Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
  • Information by UniProt

Caveolin-2 peptide (ab4929) 使用論文

ab4929 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab4929.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"