製品の概要

  • 製品名Anti-Caspr2 antibody [S67-25]
    Caspr2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [S67-25] to Caspr2
  • 特異性No cross-reactivity to CASPR/Paranodin.
  • アプリケーション適用あり: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Fusion protein(his-tagged), corresponding to the extracellular domain amino acids 96-1265 of Human Caspr2 (NP_054860).

  • ポジティブ・コントロール
    • Rat brain lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名S67-25
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab105581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 148 kDa.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
ICC/IF Use a concentration of 0.1 - 10 µg/ml.

ターゲット情報

  • 機能May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
  • 組織特異性Predominantly expressed in nervous system.
  • 関連疾患Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
    Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
    Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.
  • 配列類似性Belongs to the neurexin family.
    Contains 2 EGF-like domains.
    Contains 1 F5/8 type C domain.
    Contains 1 fibrinogen C-terminal domain.
    Contains 4 laminin G-like domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AUTS15 antibody
    • CDFE antibody
    • Cell recognition molecule Caspr2 antibody
    • CNTNAP2 antibody
    • CNTP2 antibody
    • CNTP2_HUMAN antibody
    • Contactin-associated protein-like 2 antibody
    • Homolog of Drosophila neurexin IV antibody
    • NRXN4 antibody
    • PTHSL1 antibody
    see all

Anti-Caspr2 antibody [S67-25] 画像

  • Immunohistochemical detection of CASPR2 in frozen sections of Mouse brain extract using ab105581.


  • Predicted band size : 148 kDa
    Western blot detection of CASPR2 on Rat brain membrane tissues using ab105581 at 1:1000 dilution.

Anti-Caspr2 antibody [S67-25] (ab105581) 使用論文

ab105581 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"