製品の概要

  • 製品名Anti-Caspr2 antibody
    Caspr2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Caspr2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    CDPNFTETIDESKKEWLI

    , corresponding to amino acids 1315-1331 of Human Caspr2, with an additional N terminal cysteine

  • ポジティブ・コントロール
    • Rat brain membranes

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.025% Sodium Azide
    Constituents: 5% Sucrose, 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab50206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/1000. Predicted molecular weight: 148 kDa.
    Note: Antibody dilutions should be made in buffer containing 1-3% bovine serum albumin.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
    • 組織特異性Predominantly expressed in nervous system.
    • 関連疾患Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
      Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
      Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.
    • 配列類似性Belongs to the neurexin family.
      Contains 2 EGF-like domains.
      Contains 1 F5/8 type C domain.
      Contains 1 fibrinogen C-terminal domain.
      Contains 4 laminin G-like domains.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AUTS15 antibody
      • CDFE antibody
      • Cell recognition molecule Caspr2 antibody
      • CNTNAP2 antibody
      • CNTP2 antibody
      • CNTP2_HUMAN antibody
      • Contactin-associated protein-like 2 antibody
      • Homolog of Drosophila neurexin IV antibody
      • NRXN4 antibody
      • PTHSL1 antibody
      see all

    Anti-Caspr2 antibody 画像

    • All lanes : Anti-Caspr2 antibody (ab50206) at 1/1000 dilution

      Lane 1 : Normal rat lung homogenate
      Lane 2 : Normal rat lung plasma membrane fraction
      Lane 3 : Tumor (13762) rat lung homogenate
      Lane 4 : Tumor (13762) rat lung plasma membrane fraction
      Lane 5 : Rat brain homogenate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP conjugated donkey anti-rabbit
      Developed using the ECL technique

      Performed under reducing conditions.

      Predicted band size : 148 kDa
      Observed band size : 140 kDa (why is the actual band size different from the predicted?)


      Exposure time : 3 seconds

      This image is courtesy of an anonymous Abreview

      See Abreview

    Anti-Caspr2 antibody (ab50206) 使用論文

    ab50206 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Rat Tissue lysate - whole (Brain, Tumor Lung (13762) and Normal Lung)
    Loading amount 10 µg
    Specification Brain, Tumor Lung (13762) and Normal Lung
    Gel Running Conditions Reduced Denaturing
    Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5%
    Username

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    投稿 Nov 26 2007

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"