製品の概要

  • 製品名Anti-Caspase-9 antibody [2-22]
    Caspase-9 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2-22] to Caspase-9
  • アプリケーション適用あり: IHC-P, WB, IPmore details
  • 種交差性
    交差種: Human, Monkey
  • 免疫原

    Recombinant full length protein corresponding to Human Caspase-9 (Propeptide).
    Database link: P55211

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab69541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 2 µg/ml. Detects a band of approximately 46 kDa (predicted molecular weight: 46 kDa).
IP Use a concentration of 12.5 µg/ml.

ターゲット情報

  • 機能Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
    Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
  • 組織特異性Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 発生段階Expressed at low levels in fetal heart, at moderate levels in neonate heart, and at high levels in adult heart.
  • 翻訳後修飾Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
  • Information by UniProt
  • 参照データベース
  • 別名
    • APAF-3 antibody
    • APAF3 antibody
    • Apoptosis related cysteine peptidase antibody
    • Apoptotic protease Mch-6 antibody
    • Apoptotic protease-activating factor 3 antibody
    • CASP-9 antibody
    • CASP9 antibody
    • CASP9_HUMAN antibody
    • Caspase 9 apoptosis related cysteine peptidase antibody
    • Caspase 9 Dominant Negative antibody
    • Caspase 9c antibody
    • Caspase-9 antibody
    • Caspase-9 subunit p10 antibody
    • ICE LAP6 antibody
    • ICE like apoptotic protease 6 antibody
    • ICE-LAP6 antibody
    • ICE-like apoptotic protease 6 antibody
    • MCH6 antibody
    • PPP1R56 antibody
    • protein phosphatase 1, regulatory subunit 56 antibody
    • RNCASP9 antibody
    see all

Anti-Caspase-9 antibody [2-22] 画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human uterus, vessels tissue labelling Caspase-9 with ab69541 at 10µg/ml.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human spleen tissue labelling Caspase-9 with ab69541 at 10µg/ml.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human heart tissue labelling Caspase-9 with ab69541 at 10µg/ml.

  • All lanes : Anti-Caspase-9 antibody [2-22] (ab69541)

    Lane 1 : HeLa cell lysate
    Lane 2 : Induced HeLa cell lysate


    Predicted band size : 46 kDa

Anti-Caspase-9 antibody [2-22] (ab69541) 使用論文

ab69541 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab69541.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"