Anti-Caspase-12 抗体 (ab62463)
Key features and details
- Rabbit polyclonal to Caspase-12
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Caspase-12 antibody
Caspase-12 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Caspase-12 -
由来種
Rabbit -
特異性
ab62463 can be used for the detection of both the propeptide and cleaved forms of Caspase-12. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Mouse Caspase-12.
Database link: O08736 -
ポジティブ・コントロール
- Mouse liver lysate. Rat liver lysate. Human liver tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab62463の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa). |
ターゲット情報
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機能
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. -
組織特異性
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. -
配列類似性
Belongs to the peptidase C14A family.
Contains 1 CARD domain. - Information by UniProt
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参照データベース
- Entrez Gene: 12364 Mouse
- Entrez Gene: 156117 Rat
- SwissProt: O08736 Mouse
- SwissProt: Q920D5 Rat
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別名
- CASP 12 antibody
- CASP-12 antibody
- Casp12 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab62463 は 10 報の論文で使用されています。
- Wang S et al. Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis. Am J Transl Res 14:5024-5039 (2022). PubMed: 35958489
- Zhang M et al. Hyperhomocysteinemia exacerbates acute kidney injury via increased mitochondrial damage. Front Physiol 13:967104 (2022). PubMed: 36277207
- Li S et al. Silencing of FTX suppresses pancreatic cancer cell proliferation and invasion by upregulating miR-513b-5p. BMC Cancer 21:290 (2021). PubMed: 33736615
- Xue Z et al. Klotho alleviates chronic intermittent hypoxia-induced genioglossus myocyte apoptosis by inhibiting endoplasmic reticulum stress. Exp Ther Med 22:708 (2021). PubMed: 34007317
- Chen L et al. Exogenous hydrogen sulfide protects against hepatic ischemia/reperfusion injury by inhibiting endoplasmic reticulum stress and cell apoptosis. Exp Ther Med 22:799 (2021). PubMed: 34093755
- Guo X et al. The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis. Mediators Inflamm 2021:5265444 (2021). PubMed: 34594156
- Xu Q et al. Congrong Shujing Granule-Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease Rat Model. Evid Based Complement Alternat Med 2020:4796236 (2020). PubMed: 33062012
- He B et al. Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats. Can J Physiol Pharmacol N/A:N/A (2019). PubMed: 30673309
- Luo R et al. Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells. Life Sci 228:85-97 (2019). PubMed: 31047897
- Maddalena F et al. Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca2+ homeostasis. Cancer Res 71:7659-69 (2011). WB ; Human . PubMed: 22052463