製品の概要

  • 製品名Anti-Caspase-10 antibody
    Caspase-10 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Caspase-10
  • 特異性ab25045 recognises the proform, intermediates and cleaved form of caspase-10.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-10.
    Database link: Q92851
    (Peptide available as ab41705)

  • ポジティブ・コントロール
    • Jurkat cells induced by camptothecin (2uM/ml).

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab25045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 20, 30, 34 , 55 kDa.Can be blocked with Caspase-10 peptide (ab41705).

ターゲット情報

  • 機能Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-
    -AMC and Asp-Glu-Val-Asp-
    -AMC.
    Isoform C is proteolytically inactive.
  • 組織特異性Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
  • 関連疾患Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.
    Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
    Defects in CASP10 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.
  • 翻訳後修飾Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALPS2 antibody
    • Apoptotic protease Mch-4 antibody
    • CASP 10 antibody
    • CASP-10 antibody
    • CASP10 antibody
    • CASPA_HUMAN antibody
    • Caspase 10 apoptosis related cysteine peptidase antibody
    • Caspase-10 subunit p12 antibody
    • FADD like ICE2 antibody
    • Fas associated death domain protein antibody
    • FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody
    • FLICE 2 antibody
    • FLICE2 antibody
    • ICE like apoptotic protease 4 antibody
    • ICE-like apoptotic protease 4 antibody
    • Interleukin 1B converting enzyme 2 antibody
    • MCH 4 antibody
    see all

Anti-Caspase-10 antibody 画像

  • Anti-Caspase-10 antibody (ab25045) + 2 microM/ml camptothecin treated Jurkat cells.

    Predicted band size : 20, 30, 34 , 55 kDa
    Observed band size : 20,30,34,55 kDa

Anti-Caspase-10 antibody (ab25045) 使用論文

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for your enquiry. ab25045 detects both a and b forms of caspase-10 (pro, intermediate and cleaved forms). The positive control immunoblot used on the datasheet of ab10452 was indeed tested on UNTREATED Jurkat cells. By western blottin...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"